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Use Force Quit when an application is unresponsive. Choose Force Quit from the Apple menu or press Command+Option+Esc keys. Click the name of the deviant application (it probably has not responding next to its name). You typically won’t have to reboot.
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Restart. If Force Quit doesn’t bail you out, try rebooting the computer. If a frozen Mac prevents you from clicking the Restart command on the Apple menu, hold down the power button for several seconds or press the Control+Command keys and then press the power button. If all else fails, pull the plug, but remember that powering down without logging out should be used only as a last resort.
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Restart in Safe Mode. Press the power button to turn on your computer, and then press and hold the Shift key the instant you hear the welcome chime. Release Shift when the Apple logo appears. You will see a status bar as the computer boots, after which the words Safe Boot appear in red in the upper right corner of OS X’s login screen. In Safe mode, the Mac unleashes a series of troubleshooting steps designed to return the computer to good health. If Safe Boot resolved the issue, restart the Mac normally the next time.