Bipolar Disorder For Dummies, 3rd Edition
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The following table lists several antidepressants used in the treatment of bipolar disorder besides Selective Serotonin Reuptake Inhibitors (SSRIs) and Selective Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) that affect serotonin but differ structurally from the SSRIs and SNRIs.

Two of the medications in the table are used commonly as sleep aids because they're so sedating, and some affect other neurotransmitters as well.

Potential Benefits and Side Effects of Other Serotonin-Related Antidepressants
Generic Name Brand Name Average Adult Dose Potential Benefits Some Possible Side Effects*
Mirtazapine Remeron 15 to 25 mg/day Antidepressant (approved for use in unipolar depression); very sedating (often used as a sleep aid). Suicidal ideation; agitation; disinhibition; mania; sedation; weight gain; dry mouth; increased cholesterol.
Nefazodone Serzone 300 to 600 mg/day Antidepressant (approved for use in unipolar depression); antianxiety. Suicidal ideation; agitation; disinhibition; mania; liver abnormalities (liver function should be monitored); sedation; insomnia; headache; dry mouth; constipation; muscle weakness; sexual dysfunction.
Trazodone Desyrel 150 to 600 mg/day Antidepressant (approved for use in unipolar depression); sedative (often used as a sleep aid). Suicidal ideation; agitation; disinhibition; mania; sedation; dry mouth; headache; dizziness and nausea; sexual dysfunction; priapism (an erection that doesn't stop, which can be a medical emergency).
Vilazodone Viibryd 20 to 40 mg/day Antidepressant (approved for use in unipolar depression). Suicidal ideation; agitation; disinhibition; mania; belly and gastrointestinal problems; sexual dysfunction.
Vortioxetin Brintellix 5 to 20 mg/day Antidepressant (approved for use in unipolar depression). Suicidal ideation; agitation; mania; nausea; sexual dysfunction.

mg/day = milligrams per day

* Other side effects may occur that aren't listed.

About This Article

This article is from the book:

About the book authors:

Candida Fink, MD is a psychiatrist, board certified in child, adolescent, and adult psychiatry, who specializes in working with people of all ages?and their loved ones?to manage bipolar disorder. Joe Kraynak is a professional writer who deals with bipolar in his family.

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