In this case, the sign in Roman letters makes for a good intro. It was a little darker on the shady side of the Vatican, so the photographer used a medium ISO 800 and a shutter speed of 1/320 for the sign; the building entrance was shot with a shutter speed of 1/200 with ISO 640 for the building entrance. The aperture was upped to f/14 for the entrance so that more of the entire scene would be in focus.