Visual Studio 2010 keyboard shortcuts for the general development environment increase developer productivity by allowing you to perform most common tasks without taking your hands off the keyboard.

Task You Want to Perform Feature Keyboard Shortcut
Browse data types Class View Ctrl+Shift+C
Object Browser Ctrl+Alt+J
Edit code Format Document Ctrl+K, Ctrl+D
Comment Selection Ctrl+K, Ctrl+C
Uncomment Selection Ctrl+K, Ctrl+U
Insert Code Snippet Ctrl+K, Ctrl+X
Toggle Outlining Ctrl+M
Expansion Collapse to Definitions Ctrl+M, Ctrl+O
Toggle Designer and Markup Shift+F7
View Code F7
Debug Start Debugging F5
Start without Debugging Ctrl+F5
Step Into F11
Step Over F10
Toggle Breakpoint F9
Restart Ctrl+Shift+F5
Find and replace Find Symbol Alt+F12
Quick Find Ctrl+F
Quick Replace Ctrl+H
Find help Contents Ctrl+Alt+F1
Context-sensitive help F1
Display Visual Studio Help Ctrl+F1
Help Library Manager Ctrl+Alt+F1
Search Ctrl+Alt+F3
Manage project resources Properties Window F4
Property Pages Shift+F4
Data Sources Shift+Alt+D
Server Explorer Ctrl+Alt+S
Solution Explorer Ctrl+Alt+L
Toolbox Ctrl+Alt+X
Add New Item Ctrl+Shift+A
Add Existing Item Shift+Alt+A
Build Solution Ctrl+Shift+B
Open files and projects New File Window Ctrl+N
New Project Window Ctrl+Shift+N
Open File Window Ctrl+O
Open Project Window Ctrl+Shift+O
Navigate windows Close Document Ctrl+F4
Close Tool Window Shift+Esc
Cycle Documents Ctrl+F6
IDE Navigator Ctrl+Tab
Cycle Tool Panes Alt+F6