Online Test Banks
Score higher
See Online Test Banks
eLearning
Learning anything is easy
Browse Online Courses
Mobile Apps
Learning on the go
Explore Mobile Apps
Dummies Store
Shop for books and more
Start Shopping

The Role of Vitamin D in Preventing Ovarian Cancer

Ovarian cancer may arise in the ovaries, oval-shaped organs found in pairs in the female reproductive system. Studies suggest that vitamin D plays a role in preventing and treating ovarian carcinoma. In 2009, about 21,550 cases were diagnosed and 14,600 women died of ovarian cancer in the United States. Ovarian cancer is usually a cancer of women older than age 60.

Within the ovaries, eggs are produced, along with estrogen and progesterone. The following diagram shows the location of the ovaries.

Location of the ovaries and other female reproductive organs.
Location of the ovaries and other female reproductive organs.

Ovarian cancer risk factors and symptoms

Several factors increase the risk for ovarian cancer:

  • Infertility

  • Endometriosis, in which cells of the uterus are found outside the uterus, such as on the ovaries, causing pain and bleeding, especially during menstruation

  • Postmenopausal estrogen supplementation

Factors that decrease the risk for ovarian cancer include use of combined estrogen/progesterone oral contraceptives and contraception by tubal ligation (tying off the fallopian tubes).

Ovarian cancer is associated with a number of signs and symptoms, but none that are specific to ovarian cancer. Consider the most important:

  • Back pain

  • Bloating

  • Digestive symptoms, including constipation and lack of appetite

  • A feeling of being full early

  • Irregular menstrual cycles

  • Pain in the pelvis or abdomen

  • Swollen abdomen

  • Vaginal bleeding

  • Vague lower abdominal pain

Ovarian cancer diagnosis and treatment

Ovarian cancer isn’t usually diagnosed in its early stages because it tends to cause symptoms that aren’t specific to the disease. When ovarian cancer is suspected, a pelvic examination and CT scan can diagnose it. A definitive diagnosis requires a biopsy of the mass in the ovary.

Treatment of ovarian cancer starts by surgically removing the ovary and fallopian tube. If the cancer has spread, chemotherapy is added to the treatment. Radiation therapy isn’t usually used because the ovaries are located near other vital organs.

The prognosis for ovarian cancer is poor because the diagnosis is generally made so late in the disease. Complications that may occur include fluid in the abdomen, intestinal obstruction, and spread to other organs. The five-year survival rate is 45 percent.

Vitamin D’s role in ovarian cancer

The evidence that a lack of vitamin D plays a role in the occurrence of ovarian cancer is interesting; however, this relationship isn’t secure yet. Evidence that vitamin D plays a role in preventing and treating ovarian carcinoma includes the following:

  • Calcitriol slows the growth and increases apoptosis (death) of cultured ovarian cancer cells.

  • Drugs designed to act like calcitriol inhibit the growth of ovarian cancer in animal models.

  • Results from several smaller studies suggest that higher 25-hydroxyvitamin D levels might be protective against ovarian cancer; however, a recent study that combines several smaller studies shows this may be limited to overweight women.

blog comments powered by Disqus
Advertisement

Inside Dummies.com

Dummies.com Sweepstakes

Win $500. Easy.