Configuring Tools and Settings in Windows Defender
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Click Real-Time Protection in the left pane, make any desired changes, and then click Save.
You can enable or disable real-time protection, choose whether to scan files and attachments that are downloaded via a Web browser, and choose whether to scan programs that are running on your computer. Real-time Protection allows Windows Defender to scan programs for spyware or other threats automatically as they are accessed on your computer or over the Internet.