Insect and disease killers that come from plant extracts are called botanical pesticides or botanicals. Although derived from natural sources, botanicals are not necessarily safer or less toxic to non-pest insects, humans, and animals than synthetically derived pesticides. In fact, most botanicals are broad-spectrum insecticides, which kill both good and bad bugs indiscriminately. Some botanicals cause allergic reactions in people, others are highly toxic to fish and animals, and some may even cause cancer. All pesticides — including botanicals — should be used only as a last resort after thoroughly reading the label on the package. The pesticides in this section are listed from least to most toxic to humans.